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Updated: Apr 5, 2026
08:37
Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
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Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm
Hiroki Tanaka1, Nobuhiro Zaima2, Takeshi Sasaki3
1Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Plos One
|August 27, 2015
Summary
Reduced blood flow in the aortic wall
Area of Science:
- Vascular Biology
- Aortic Disease Research
Background:
- The aortic wall relies on adventitial vasa vasorum (VV) for perfusion.
- Tissue hypoxia is a known feature of enlarged abdominal aortic aneurysms (AAAs).
Purpose of the Study:
- To investigate if hypoperfusion of adventitial VV can cause abdominal aortic aneurysms (AAAs).
Main Methods:
- A novel rat model was developed using catheter insertion and aortic ligation to induce VV hypoperfusion.
- Morphological and pathological characteristics of the induced AAA were compared to human AAA.
Main Results:
- Induced VV hypoperfusion led to tissue hypoxia and the development of infrarenal AAAs in rats.
- Human AAA tissue, regardless of size, showed stenotic adventitial VV, with ischemic and hypoxic sac tissue.
Conclusions:
- Hypoperfusion of adventitial VV is a critical factor in the development of infrarenal abdominal aortic aneurysms.
- Findings suggest a direct link between compromised VV blood supply and AAA pathogenesis.
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