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Lung function changes in mice sensitized to ammonium hexachloroplatinate.

W C Williams¹, J R Lehmann¹, E Boykin¹

¹a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL), US Environmental Protection Agency , Research Triangle Park , NC , USA and.

Inhalation Toxicology

|August 27, 2015

Summary

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Platinum salts, like ammonium hexachloroplatinate (AHCP), can cause asthma. This study developed a mouse model to show AHCP causes hypersensitivity and lung function changes, indicating potential risks from platinum exposure.

Area of Science:

Immunology
Occupational Health
Toxicology

Background:

Occupational exposure to halogenated platinum salts is a known cause of asthma.
The public health risk from platinum in catalytic converters and diesel fuel is not well understood.

Purpose of the Study:

To investigate pulmonary responses to platinum exposure.
To develop a mouse model for studying platinum hypersensitivity.

Main Methods:

Mice were sensitized with ammonium hexachloroplatinate (AHCP) via topical application.
Pulmonary responses were assessed using whole body plethysmography (WBP) after oropharyngeal aspiration challenge.
Lymph node cell counts and bronchoalveolar lavage fluid were analyzed.

Main Results:

Keywords:

Ammonium hexachloroplatinate occupational asthma platinum pulmonary hyperresponsiveness respiratory hypersensitivity whole-body plethysmography

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AHCP-sensitized mice showed a dose-dependent increase in immediate pulmonary responses.
Methacholine responsiveness significantly increased in sensitized mice.
Elevated eosinophils and total serum immunoglobulin E were observed in sensitized mice.

Conclusions:

The developed mouse model effectively demonstrates platinum hypersensitivity.
Platinum exposure can lead to significant changes in lung function and immune responses.
Further research is needed to assess population-level risks from environmental platinum exposure.