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Pattern of Adverse Drug Reactions in Children Attending the Department of Pediatrics in a Tertiary Care Center: A

Kishour Kumar Digra1, Aakash Pandita1, G S Saini1

  • 1Department of Pediatrics, SMGS hospital, Jammu, India.

Clinical Medicine Insights. Pediatrics
|August 27, 2015
PubMed

Insights

Adverse drug reactions (ADRs) are common in children, with anticonvulsants and antibiotics being frequent causes. This study highlights the need for improved pediatric drug safety monitoring to prevent adverse events.

Area of Science:

  • Pediatric Pharmacology
  • Clinical Toxicology
  • Drug Safety Surveillance

Background:

  • Adverse drug reactions (ADRs) pose a significant risk in pediatric populations.
  • Understanding the patterns of ADRs is crucial for enhancing drug safety in children.

Purpose of the Study:

  • To investigate the incidence and characteristics of ADRs in pediatric patients at SMGS Hospital, Jammu.
  • To identify the most common drug classes and clinical manifestations associated with ADRs in children.

Main Methods:

  • A prospective study was conducted over one year involving pediatric patients.
  • Data on ADRs were collected using a structured format and analyzed for probability (Naranjo scale) and severity (Hartwig scale).
  • ADRs were classified according to the Adverse Drug Reaction Monitoring Center guidelines.

Main Results:

  • 104 pediatric patients experienced acute drug reactions, with Type B reactions being most prevalent (83.6%).
  • Anticonvulsants (25.96%) and antibiotics (22.11%) were the leading causes of ADRs.
  • Dermatological manifestations (67.30%) were the most common, followed by central nervous system involvement (11.53%). Moderate severity ADRs were observed in 64.4% of patients.

Conclusions:

  • ADRs are frequent in children aged 1-5 years (71%).
  • Rash is the most common presentation (55.76%) of ADRs.
  • There is a critical need for rigorous adverse drug monitoring in pediatric care to ensure therapeutic safety.
Abstract

Keywords:
ADRantibioticsdrug reactionpaediatricsrashsafe practice

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