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Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
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Association of hOGG1 Ser326Cys polymorphism with susceptibility to hepatocellular carcinoma

Jun Guo1, Jing Yang2, Yan Li1

  • 1Department of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.

International Journal of Clinical and Experimental Medicine
|August 27, 2015
PubMed

Insights

The hOGG1 Ser326Cys polymorphism is linked to a higher risk of developing hepatocellular carcinoma (HCC). This meta-analysis confirms a significant association between this genetic variation and increased susceptibility to HCC.

Area of Science:

  • Genetics and Genomics
  • Cancer Research
  • Molecular Epidemiology

Background:

  • The association between the hOGG1 Ser326Cys polymorphism and hepatocellular carcinoma (HCC) risk has yielded inconsistent findings in previous studies.
  • This meta-analysis aims to provide a more precise estimation of this relationship by synthesizing existing evidence.

Purpose of the Study:

  • To evaluate the association between the hOGG1 Ser326Cys polymorphism and the risk of developing HCC.
  • To clarify the conflicting results reported in the literature regarding this genetic polymorphism and HCC susceptibility.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, CBM, and EMBASE databases.
  • Nine case-control studies, including 2583 HCC patients and 2271 controls, were included in this meta-analysis.
  • Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed-effect or random-effect models based on heterogeneity.

Main Results:

  • The hOGG1 Ser326Cys polymorphism was significantly associated with an increased risk of HCC across various genetic models (e.g., GG vs. CC: OR=2.51, 95% CI=1.67-3.78).
  • Subgroup analyses by ethnicity indicated a higher HCC risk in Asians with GG and GG+CG genotypes.
  • The association remained significant in both hospital-based and population-based control groups.

Conclusions:

  • The hOGG1 Ser326Cys polymorphism is confirmed to be associated with an elevated risk of hepatocellular carcinoma.
  • This finding contributes to a clearer understanding of the genetic factors influencing HCC development.
Abstract

Keywords:
Human 8-oxoguanine glycosylase 1Ser326Cyshepatocellular carcinomarisk

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