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Updated: Apr 5, 2026
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
TP53 codon 72 polymorphism and susceptibility to cervical cancer in the Chinese population: an update meta-analysis
Bing Li1, Xin Wang1, Hong Chen2
1Department of Gynecology and Obstetrics, Anhui Medical University Affiliated Military General Hospital of Beijing PLA Cilnical College Beijing 100700, People's Republic of China.
Background:
Although many epidemiologic studies investigated the TP53 codon 72 polymorphism and its association with cervical cancer (CC), definite conclusions cannot be drawn.
Aim Of The Study:
To evaluate the association between TP53 codon 72 polymorphism and risk of cervical cancer in the Chinese population.
Methods:
A computerized literature search was carried out in PubMed, Springer Link, Ovid, Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database to collect relevant articles. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.
Results:
A total of 16 studies including 1684 CC cases and 1178 controls were involved in this meta-analysis. Overall, significant increased association was found between the Pro/Pro carriers and CC risk when all studies in Chinese population pooled into the meta-analysis (heterozygous model: OR = 1.22, 95% CI: 1.01-1.46). In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Han and in hospital-based studies.
Conclusion:
Our results suggest that the TP53 codon 72 polymorphism may be potential biomarkers for CC risk in the Chinese population, especially for Han Chinese, and studies with wider spectrum of population are required for definite conclusions.
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