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Pemetrexed induced a durable response in heavily pretreated metastatic extramammary Paget's disease
Chao Wu1, Hai-Tao Tao1, Fang-Fang Li2
1Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
Purpose:
Extramammary Paget's disease (EMPD) is a rare neoplasm with only a limited number of cases reported in the literature. Little was known about the availability of systemic chemotherapy for metastatic EMPD.
Methods:
We report one case of heavily pretreated EMPD with multiple organ metastases and successfully treated by pemetrexed.
Result:
The tumor was progression after multi-line therapy including erlotinib, radiotherapy, combined chemotherapy and radioactive particles implantation. Pemetrexed monotherapy was applied and progression free survival of more than 5 months with partial remission (PR) response was achieved. Only 1 time of grade 3 neutropenia was observed during the pemetrexed chemotherapy.
Conclusion:
Due to the significant response and tolerability in the present case, pemetrexed monotherapy was recommended as a potent candidate for patients with advanced EMPD.
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