Application of continuous renal replacement therapy for acute kidney injury in elderly patients

This study aims to analyze the factors that affect the prognosis of continuous renal replacement therapy (CRRT) in elderly patients with acute kidney injury (AKI). Data obtained from 41 elderly patients with AKI who underwent CRRT in our department between January 2001 and December 2010 was retrospectively evaluated in this study. The enrolled patients were 80 to 100 years old, with a mortality of 60.98%. The mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 27.8±5.6 points, and the mean risk coefficient was 0.80±0.10. The APACHE II score of the survival group was significantly higher than that of the death group. The comparisons of therapeutic dosages between <25 mL/(kg⋅h) and 25-50 mL/(kg⋅h), and between 25-50 mL/(kg⋅h) and >50 mL/(kg⋅h) all had no statistical significance. The prognosis of CRRT and the number of involved organs were related to the APACHE II score. Logistic regression analysis revealed that the number of involved organ, APACHE II score, mechanical ventilation, and hypoalbuminemia were the major risk coefficients that affected the prognosis of patients with bedside hemofiltration. The turnover of elderly CRRT patients was related to the number of involved organs, APACHE II score, mechanical ventilation, hypoalbuminemia, and other factors. The APACHE II score was the important reference index of CRRT starting time and could predict mortality risk.