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Brexpiprazole: First Global Approval.
1Springer, Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand. dru@adis.com.
Brexpiprazole (Rexulti®) is an atypical antipsychotic approved for major depressive disorder and schizophrenia. It modulates serotonin and dopamine activity, offering a new treatment option for psychiatric disorders.
Area of Science:
- Psychiatry
- Pharmacology
- Neuroscience
Background:
- Brexpiprazole (Rexulti®) is an atypical antipsychotic developed for psychiatric disorders.
- It functions as a serotonin-dopamine activity modulator.
Purpose of the Study:
- To summarize the development milestones of brexpiprazole.
- To highlight its first global approval for major depressive disorder (MDD) and schizophrenia.
Main Methods:
- Review of development history and regulatory approvals.
- Analysis of brexpiprazole's pharmacological profile.
Main Results:
- Brexpiprazole received US approval in July 2015 for adjunctive MDD treatment and schizophrenia.
- It acts as a partial agonist for serotonin 1A (5-HT1A) and dopamine D2 receptors.
- It is also a potent antagonist for 5-HT2A and noradrenergic α1B/α2C receptors.
Conclusions:
- Brexpiprazole represents a significant advancement in the treatment of major depressive disorder and schizophrenia.
- Its novel mechanism of action offers a new therapeutic avenue for psychiatric conditions.
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