Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

1.6K
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
1.6K
Aquaporins01:25

Aquaporins

7.0K
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
7.0K
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

44.6K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
44.6K
Facilitated Diffusion01:16

Facilitated Diffusion

1.6K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.6K
Membrane Transporters01:31

Membrane Transporters

19.7K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
19.7K
Secondary Active Transport01:32

Secondary Active Transport

13.7K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paradigm shift in inflammatory bowel disease management-advanced therapy utilization, persistence, and outcomes in a United Arab Emirates cohort during 2015-2025.

Crohn's & colitis 360·2026
Same author

Exploring chalcone-based azo dyes as potential carbonic anhydrase-I/II inhibitors through experimental and computational studies.

Bioorganic chemistry·2026
Same author

Real-world effectiveness of guselkumab for induction of remission in Crohn's disease: a prospective multicenter cohort study with propensity score-matched comparison to risankizumab.

Crohn's & colitis 360·2026
Same author

Ion-Track-Etched Membranes as Nanoionic Platforms: Fabrication, Nanoscale Ion Transport, and Device Applications─A Review.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Primer choice shapes microbial community interpretation across habitats and informs short-term structured enrichment in environmental and applied systems.

Frontiers in microbiology·2026
Same author

Chalcone-sulfonate ester derivatives as dual urease and α-amylase inhibitors: synthesis, biological evaluation and integrated computational studies.

RSC advances·2026

Related Experiment Video

Updated: Apr 5, 2026

High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.2K

Ionic Transport through Chemically Functionalized Hydrogen Peroxide-Sensitive Asymmetric Nanopores.

Mubarak Ali1,2, Ishtiaq Ahmed3, Saima Nasir1,2

  • 1Department of Material- and Geo-Sciences, Materials Analysis, Technische Universität Darmstadt , D-64287 Darmstadt, Germany.

ACS Applied Materials & Interfaces
|August 28, 2015
PubMed
Summary

We developed a nanofluidic sensor using asymmetric nanopores that detects hydrogen peroxide (H2O2). This device monitors H2O2 levels by measuring changes in electrical current, showing promise for medical diagnostics.

Keywords:
H2O2-sensitive poreNernst−Planck equationsasymmetric nanoporeschemical functionalizationcurrent rectification

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.3K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.3K

Related Experiment Videos

Last Updated: Apr 5, 2026

High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.2K
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.3K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.3K

Area of Science:

  • Nanofluidics
  • Chemical Sensing
  • Materials Science

Background:

  • Nanofluidic devices offer unique platforms for chemical detection.
  • Asymmetric nanopores exhibit tunable transport properties.
  • Hydrogen peroxide (H2O2) is a key biomarker in various medical diagnostics.

Discussion:

  • Experimental and theoretical validation of H2O2-mediated changes in current-voltage curves.
  • Demonstration of electronic readout for monitoring surface property alterations.
  • Scaling single pore behavior to multipore membranes for controlled electric outputs.

Key Insights:

  • Asymmetric nanopores enable modulation of nanofluidic transport by H2O2.
  • Current-voltage characteristics serve as a reliable electronic readout for H2O2 detection.
  • Scalability of the device from single pores to membranes facilitates practical applications.

Outlook:

  • Potential for developing advanced H2O2 sensing devices for medical diagnostics.
  • Future applications in point-of-care testing and environmental monitoring.
  • Further research into other chemical analytes and advanced nanofluidic architectures.