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Changes in cardiovascular health score and atherosclerosis progression in middle-aged and older persons in China: a

Jingsheng Gao1, Minghui Bao2, Yan Liu1

  • 1Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, China.

BMJ Open
|August 28, 2015
PubMed

Insights

Improving cardiovascular health score (CHS) is linked to reduced atherosclerosis progression. An increased CHS is associated with a significant decrease in brachial-ankle pulse wave velocity (baPWV), a key indicator of arterial stiffness.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Public Health

Background:

  • The American Heart Association (AHA) defined 7 metrics for cardiovascular health.
  • The Cardiovascular Health Score (CHS) estimates individual cardiovascular health status.
  • Changes in CHS (⊿CHS) may reflect changes in atherosclerosis progression.

Purpose of the Study:

  • To investigate the association between changes in CHS (⊿CHS) and atherosclerosis progression.
  • To analyze the relationship between ⊿CHS and changes in brachial-ankle pulse wave velocity (⊿baPWV) in middle-aged and older adults.

Main Methods:

  • Prospective cohort study in China with 3951 participants (≥40 years old).
  • Participants were categorized into 8 groups based on ⊿CHS.
  • Analysis of ⊿baPWV and atherosclerosis progression in relation to ⊿CHS.

Main Results:

  • A significant trend of decreasing ⊿baPWV was observed with increasing ⊿CHS (p for trend<0.05).
  • Multivariate analysis revealed a negative association between ⊿CHS and ⊿baPWV, independent of other risk factors.
  • Each unit increase in CHS was associated with a 15.22 cm/s reduction in baPWV (B = -15.22, p<0.001).

Conclusions:

  • Changes in cardiovascular health score (⊿CHS) are negatively related to changes in brachial-ankle pulse wave velocity (⊿baPWV).
  • ⊿baPWV is an independent predictor of atherosclerosis progression in middle-aged and older individuals.
Abstract

Keywords:
CARDIOLOGY

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