Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ψ(2S) Suppression in Pb-Pb Collisions at the LHC.

Physical review letters·2024
Same author

Measurements of Groomed-Jet Substructure of Charm Jets Tagged by D^{0} Mesons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Measurement of the Lifetime and Λ Separation Energy of _{Λ}^{3}H.

Physical review letters·2023
Same author

Measurement of the J/ψ Polarization with Respect to the Event Plane in Pb-Pb Collisions at the LHC.

Physical review letters·2023
Same author

Enhanced Deuteron Coalescence Probability in Jets.

Physical review letters·2023
Same author

First Measurement of Antideuteron Number Fluctuations at Energies Available at the Large Hadron Collider.

Physical review letters·2023

Related Experiment Video

Updated: Jul 25, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

10.3K

Bone Aging by Advanced Glycation End Products: A Multiscale Mechanical Analysis.

K Ganeko1, C Masaki1, Y Shibata2

  • 1Department of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan.

Journal of Dental Research
|August 28, 2015
PubMed
Summary

Aging impairs bone toughness by increasing nonenzymatic cross-links, reducing fracture resistance. This study mimics aging in rabbits, revealing diminished bone toughening mechanisms at the nanoscale.

Keywords:
Raman spectroscopybiomechanical phenomenacollagenelasticityhardness testsmethionine

More Related Videos

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.1K
Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps
10:55

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Published on: January 31, 2025

1.1K

Related Experiment Videos

Last Updated: Jul 25, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

10.3K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.1K
Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps
10:55

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Published on: January 31, 2025

1.1K

Area of Science:

  • Biomaterials Science
  • Skeletal Biology
  • Mechanical Engineering

Background:

  • Mandibular bone quality is crucial for dental implant success, with Hounsfield units (HU) being the current clinical index.
  • Existing HU measures do not fully correlate with bone quality, highlighting a need for better indicators.
  • Aging is empirically linked to reduced bone toughness, but mechanical evidence is lacking, particularly concerning nonenzymatic cross-linking.

Purpose of the Study:

  • To investigate the impact of aging-mimicking conditions on bone mechanical properties and toughening mechanisms.
  • To explore the role of nonenzymatic cross-linking in age-related bone quality decline.
  • To establish a precise protocol for evaluating bone mechanical properties at the material level.

Main Methods:

  • Mimicking aging in rabbits using a methionine-rich diet to enhance nonenzymatic bone matrix cross-links.
  • Conducting 3-point bending tests on femurs to assess fracture resistance.
  • Performing in situ nanoindentation on mandibular cortical bone to evaluate nanoscale mechanical behavior and strain rate-dependent stiffening.

Main Results:

  • Rabbits on a methionine-rich diet exhibited reduced femoral fracture resistance compared to controls, despite higher maximum breaking forces.
  • Mandibular bone from rabbits on the methionine-rich diet failed to show strain rate-dependent stiffening during nanoindentation.
  • The impaired strain rate-dependent stiffening suggests a diminished bone toughening mechanism due to altered matrix cross-linking.

Conclusions:

  • Enhanced nonenzymatic cross-linking, mimicking aging, impairs the bone toughening mechanism and reduces fracture resistance.
  • Nanoscale mechanical properties, specifically strain rate-dependent stiffening, are critical for bone's resistance to cracking and overall toughness.
  • The study provides a validated protocol for material-level assessment of bone mechanical properties, crucial for understanding age-related changes and implantology.