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Summary
Laryngeal keratosis rarely transforms into cancer, with a 3.26% observed rate in a 5-year study. Literature review supports a low but predictable risk of malignancy in laryngeal keratosis.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Laryngeal keratosis is a premalignant lesion.
- The risk of malignant transformation is debated.
Purpose of the Study:
- To determine the frequency of laryngeal carcinoma development in laryngeal keratoses.
- To evaluate clinicopathologic correlations for keratosis grading.
Main Methods:
- A retrospective study of 92 laryngeal keratosis cases with ≥5 years follow-up.
- Literature review of studies using strict pathologic criteria for laryngeal keratosis.
Main Results:
- Three patients (3.26%) developed laryngeal carcinoma.
- Literature data indicates a 3.33%-4.31% malignant transformation rate.
Conclusions:
- Laryngeal keratosis has a low but predictable risk of developing into laryngeal carcinoma.
- A grading system for keratosis is proposed for clinicopathologic correlation.