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A Murine Model of Subarachnoid Hemorrhage
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High rate of microbleed formation following primary intracerebral hemorrhage

Jason Mackey1, Jeffrey J Wing2, Gina Norato3

  • 1Department of Neurology, Indiana University, Indianapolis, IN, USA.

International Journal of Stroke : Official Journal of the International Stroke Society
|August 28, 2015
PubMed
Abstract

Insights

One-third of intracerebral hemorrhage survivors developed new microbleeds within a year, indicating a progressive vasculopathy. The baseline number of microbleeds and age predicted new microbleed formation.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Intracerebral hemorrhage (ICH) survivors are at risk for developing new microbleeds.
  • Understanding the frequency and predictors of new microbleeds is crucial for patient management.
  • Previous studies have not sufficiently focused on microbleed development in diverse populations.

Purpose of the Study:

  • To determine the incidence of new microbleed formation after ICH.
  • To identify clinical and imaging predictors of new microbleed development.
  • To investigate these factors in a predominantly African-American cohort.

Main Methods:

  • Prospective, longitudinal, magnetic resonance imaging (MRI)-based cohort study (DECIPHER).
  • Evaluation of new microbleed formation at two time points: baseline to 30 days and 30 days to 1 year.
  • Logistic regression analysis to identify predictors of new microbleed formation.

Main Results:

  • Of 84 eligible subjects, 13.1% developed new microbleeds by 30 days and 29.8% by 1 year.
  • The baseline number of microbleeds predicted new microbleed formation at 30 days (OR 1.05, P=0.01).
  • Predictors for new microbleeds at 1 year included baseline microbleed count (OR 1.05, P=0.046), age (OR 1.05, P=0.04), and white matter disease score (OR 1.18, P=0.115).

Conclusions:

  • Approximately one-third of ICH survivors in this cohort developed new microbleeds within the first year.
  • This suggests a dynamic and progressive underlying vasculopathy following ICH.
  • Further research is warranted to explore the clinical impact of new microbleed formation on patient outcomes.
Keywords:
MRIbrain bleedbrain microbleedscerebral hemorrhagehemorrhageintracerebral hemorrhage

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