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Related Concept Videos

Hepatitis01:25

Hepatitis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Related Experiment Video

Updated: Apr 5, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
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Glomerular Diseases Associated With Hepatitis B and C.

Anu Gupta1, Richard J Quigg1

  • 1Department of Medicine, Division of Nephrology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY.

Advances in Chronic Kidney Disease
|August 28, 2015
PubMed
Summary

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections can cause glomerulonephritis (GN). Treatment focuses on antiviral therapies for HBV-GN and a combination of antiviral and immunomodulatory agents for HCV-related GN.

Keywords:
CryoglobulinemiaGlomerulonephritisHepatitis BHepatitis C

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are global health concerns.
  • These viral infections are associated with various kidney diseases, particularly glomerulonephritis (GN).

Purpose of the Study:

  • To review the epidemiology, pathogenesis, clinical features, and treatment of HBV- and HCV-related GN.
  • To provide an overview of the current understanding and management strategies for these conditions.

Main Methods:

  • Literature review of studies on HBV- and HCV-related glomerulonephritis.
  • Synthesis of information on disease presentation, mechanisms, and therapeutic interventions.

Main Results:

  • HBV-GN commonly presents as membranous nephropathy, driven by immune complexes, treated with antivirals.
  • HCV-GN includes membranoproliferative glomerulonephritis (MPGN), often linked to cryoglobulinemia, managed with antivirals and immunomodulators.

Conclusions:

  • HBV- and HCV-related GN are significant renal complications of viral hepatitis.
  • Effective management relies on targeted antiviral therapy, with immunomodulation playing a role in HCV-associated cases.