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Current Management of Chronic Hepatitis B and C in Chronic Kidney Disease

Adam E Mikolajczyk1, Andrew I Aronsohn1

  • 1Department of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL.

Advances in Chronic Kidney Disease
|August 28, 2015
PubMed

Insights

Novel oral antiviral therapies effectively manage chronic hepatitis B (HBV) and cure hepatitis C (HCV). This review examines their use in patients with chronic kidney disease (CKD) due to limited trial data.

Area of Science:

  • Hepatology
  • Nephrology
  • Infectious Diseases

Background:

  • Therapeutic options for hepatitis B (HBV) and hepatitis C (HCV) have advanced significantly.
  • Novel oral antiviral agents offer effective treatment for chronic HBV and curative potential for chronic HCV.
  • Patients with chronic kidney disease (CKD) were underrepresented in clinical trials for these antivirals.

Purpose of the Study:

  • To review current data on novel antiviral therapies for HBV and HCV in patients with CKD.
  • To address the challenges posed by limited data and comorbidities in treating viral hepatitis in CKD patients.
  • To provide guidance for physicians managing HBV and HCV in the context of kidney insufficiency.

Main Methods:

  • Literature review of studies on antiviral therapies for HBV and HCV.
  • Analysis of data concerning efficacy and safety in CKD populations.
  • Synthesis of information on challenges and considerations for CKD patients.

Main Results:

  • Emerging data suggest potential efficacy of novel antivirals in CKD.
  • Specific dosing and monitoring considerations are crucial for CKD patients.
  • Further research is needed to establish optimal treatment protocols.

Conclusions:

  • Novel antiviral therapies hold promise for HBV and HCV treatment in CKD patients.
  • Careful patient selection and management are essential.
  • Bridging the data gap is critical for evidence-based practice.

Keywords:
HBVHCVKidney diseaseTherapy

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