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Related Experiment Videos

Chronobiologic reference values in clinical chemistry.

G Y Nicolau1, E Haus

  • 1C.I. Parhon Institute of Endocrinology, Bucharest, Romania.

Endocrinologie
|October 1, 1989
PubMed
Summary
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This study investigated daily (circadian) and yearly (circannual) rhythms in 23 biochemical markers across children, adults, and the elderly. Many parameters exhibited significant rhythms, highlighting the need for time-specific reference ranges in diagnostics.

Area of Science:

  • Chronobiology
  • Human Physiology
  • Biochemistry

Background:

  • Biological rhythms, including circadian and circannual, influence physiological processes.
  • Understanding these rhythms is crucial for accurate clinical interpretation of biochemical data.
  • Age-related variations in biological rhythms are not fully characterized.

Purpose of the Study:

  • To investigate circadian and circannual rhythms of 23 serum biochemical parameters.
  • To analyze these rhythms across different age groups: children, young adults, and the elderly.
  • To assess seasonal variations in these biochemical rhythms.

Main Methods:

  • Population mean cosinor analysis for circadian rhythms.
  • Single cosinor and ANOVA for circannual rhythms.

Related Experiment Videos

  • Study involved 194 children, 43 young adults, and 200 elderly subjects.

    • Main Results:

    • Circadian rhythms were identified in most of the 23 biochemical parameters studied.
    • Circannual rhythms were observed in a significant number of parameters.
    • Rhythm characteristics were summarized using cosinor analysis.

    Conclusions:

    • Many laboratory parameters exhibit high-amplitude rhythms, necessitating time-qualified reference ranges for clinical diagnosis.
    • Most parameters show low-amplitude rhythms, indicating the complex temporal organization of the human body.
    • These findings underscore the importance of considering biological time in health and disease.