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The association between blood pressure level and serum uric acid concentration in hemodialysis patients

Jamshid Roozbeh1, Mohammad-Mahdi Sagheb2, Elaheh Vafaie3

  • 1Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of Nephropathology
|August 28, 2015
PubMed

Insights

High uric acid levels showed a paradoxical association with higher systolic blood pressure, mean arterial pressure, and wide pulse pressure in hemodialysis patients. These findings suggest reverse epidemiology may influence these relationships.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Hypertension is prevalent in hemodialysis patients.
  • Elevated uric acid levels are common in this population due to impaired clearance.
  • Previous animal studies suggested a positive correlation between uric acid and blood pressure.

Purpose of the Study:

  • To investigate the impact of elevated serum uric acid on blood pressure parameters in hemodialysis patients.
  • To explore the relationship between hyperuricemia and various blood pressure metrics, including systolic, diastolic, mean arterial pressure, and pulse pressure.

Main Methods:

  • A study involving 91 patients undergoing thrice-weekly hemodialysis.
  • Measurement of serum uric acid and blood pressure (pre-, during, and post-dialysis).
  • Statistical analysis using SPSS 15, with significance set at P < 0.05.

Main Results:

  • 44% of patients had elevated uric acid (≥6 mg/dl).
  • Significant inverse associations were observed between hyperuricemia and high systolic pressure (OR=0.352), high MAP (OR=0.382), and wide pulse pressure (OR=0.416).
  • No significant association was found between high uric acid and diastolic pressure or inter-dialysis hypotension.

Conclusions:

  • A paradoxical inverse relationship exists between high uric acid levels and elevated systolic pressure, MAP, and wide pulse pressure in hemodialysis patients.
  • This association appears independent of dialysis duration, efficacy, and nutritional status.
  • The findings may reflect reverse epidemiology phenomena common in dialysis populations.
Abstract

Keywords:
Blood pressureHemodialysisUric acid

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