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The Tutoplast Approach: Preventing Conjunctival Erosion After Retisert Implantation

Kishan Gupta1, Colin A McCannel

  • 1*Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; and †Medical Scientist Training Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.

Retina (Philadelphia, Pa.)
|August 28, 2015
PubMed
Abstract

No abstract available in PubMed .

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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