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Wolf's isotopic response, presenting as lichen planus
Mariana Thomaz da Silva Queiroz1, José Roberto Paes de Almeida1, Ângelo Sementilli2
1Centro Universitário Lusíada, Santos, SP, BR.
Anais Brasileiros De Dermatologia
|August 28, 2015
Summary
Wolf's isotopic response is a new skin condition appearing at a healed disease site, often following herpes zoster. This case highlights lichen planus as a rare isotopic response, requiring further research into its cause.
Area of Science:
- Dermatology
- Pathology
- Immunology
Background:
- Wolf's isotopic response is a phenomenon where a new skin disease arises at the site of a previously healed, unrelated skin condition.
- Herpes zoster is the most common preceding condition, with various dermatoses like granulomatous reactions, hematologic infiltrates, tumors, and infections reported.
- Lichen planus as an isotopic response is infrequently documented.
Observation:
- A 74-year-old woman presented with multiple pruritic, rose-colored, shiny papules.
- These lesions emerged specifically at the sites of prior, resolved herpes zoster infection on her right arm and shoulder.
Findings:
- The observed dermatosis was consistent with lichen planus.
- This case represents a rare instance of lichen planus manifesting as Wolf's isotopic response.
Implications:
- The pathogenesis of Wolf's isotopic response remains poorly understood, necessitating further investigation.
- Recognition of lichen planus as a potential isotopic response broadens the differential diagnosis for new lesions at old disease sites.
- Continued research is crucial for elucidating the underlying mechanisms and clinical significance of this phenomenon.
