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Wolf's isotopic response, presenting as lichen planus.

Mariana Thomaz da Silva Queiroz1, José Roberto Paes de Almeida1, Ângelo Sementilli2

  • 1Centro Universitário Lusíada, Santos, SP, BR.

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Wolf's isotopic response is a new skin condition appearing at a healed disease site, often following herpes zoster. This case highlights lichen planus as a rare isotopic response, requiring further research into its cause.

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Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Wolf's isotopic response is a phenomenon where a new skin disease arises at the site of a previously healed, unrelated skin condition.
  • Herpes zoster is the most common preceding condition, with various dermatoses like granulomatous reactions, hematologic infiltrates, tumors, and infections reported.
  • Lichen planus as an isotopic response is infrequently documented.

Observation:

  • A 74-year-old woman presented with multiple pruritic, rose-colored, shiny papules.
  • These lesions emerged specifically at the sites of prior, resolved herpes zoster infection on her right arm and shoulder.

Findings:

  • The observed dermatosis was consistent with lichen planus.
  • This case represents a rare instance of lichen planus manifesting as Wolf's isotopic response.

Implications:

  • The pathogenesis of Wolf's isotopic response remains poorly understood, necessitating further investigation.
  • Recognition of lichen planus as a potential isotopic response broadens the differential diagnosis for new lesions at old disease sites.
  • Continued research is crucial for elucidating the underlying mechanisms and clinical significance of this phenomenon.