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Author Spotlight: Cryopreservation of Whole Blood Samples for High Throughput Analysis
Published on: February 23, 2024
A Simple Method for Human Whole Blood Microcultures and Its Application in Radiation Biodosimetry
Guo Yan1, Zhang Wen, Gao Chaoxian
1*Shenzhen Major Occupation Disease Diagnosis and Treatment Technology Key Laboratory, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.
Abstract:
The scoring of the cytokinesis-block micronucleus and dicentric chromosomes in human peripheral blood lymphocytes is used as a dosimeter of radiation exposure. A detailed methodology is presented for human whole blood microculture for cytogenetic analysis. The technique described yields more than sufficient numbers of mitotic lymphocytes for analyzing micronuclei and chromosome aberrations following exposure to radiation.
