Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

8.0K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
8.0K
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

979
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
979
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

1.1K
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
1.1K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

835
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
835
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

759
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
759
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

4.1K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Influencing Functional Recovery in People After Chronic Critical Illness During Early Neurological Rehabilitation.

Journal of multidisciplinary healthcare·2026
Same author

Eagle's Syndrome Presenting With Peripheral Facial Palsy-A Case Report.

Head & neck·2026
Same author

Reliability and minimal clinically important differences of gait characteristics in peripheral vestibular disorders.

Frontiers in neurology·2026
Same author

Use of Deep Learning Models in the Diagnosis of Proptosis Through Orbital Magnetic Resonance Imaging.

Medical science monitor : international medical journal of experimental and clinical research·2026
Same author

Evaluation of a multidisciplinary neurological rehabilitation program for the post-COVID-19 condition.

Journal of neurology·2026
Same author

A longitudinal bifactor approach to modelling somatic symptom development in psychosomatic treatment.

Journal of psychosomatic research·2026

Related Experiment Video

Updated: Apr 4, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.8K

Opioid-Induced Nausea Involves a Vestibular Problem Preventable by Head-Rest.

Nadine Lehnen1, Fabian Heuser2, Murat Sağlam3

  • 1Centre for Sensorimotor Research, Munich University Hospital, Munich, Germany; German Centre for Vertigo and Balance Disorders, Munich University Hospital, Munich, Germany; Department of Neurology, Munich University Hospital, Munich, Germany.

Plos One
|August 28, 2015
PubMed
Summary

Opioid use can cause nausea by impairing the vestibular system

More Related Videos

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.9K
Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

9.0K

Related Experiment Videos

Last Updated: Apr 4, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.8K
Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.9K
Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

9.0K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Vestibular System

Background:

  • Opioids are essential for pain management but frequently induce nausea and vomiting.
  • The precise mechanism behind opioid-induced nausea remains unclear.
  • This study investigates the role of the vestibular system in opioid-induced nausea.

Purpose of the Study:

  • To determine if opioid administration affects the vestibular system and head motion sensation.
  • To investigate if impaired vestibular function by opioids causes nausea.
  • To assess if head-rest can prevent opioid-induced nausea.

Main Methods:

  • Thirty-six healthy males received remifentanil infusions.
  • Vestibulo-ocular reflex (VOR) gain was measured using video-head-impulse-testing.
  • Nausea was quantified psychophysically, and head movements were induced under various conditions.

Main Results:

  • Remifentanil administration significantly decreased VOR gain, which recovered post-infusion.
  • Head movements, both head-trunk and isolated head rotations, triggered nausea in 64% of participants.
  • No significant difference in nausea was observed between head-trunk and isolated head movements.

Conclusions:

  • Opioid-induced nausea may result from a decreased VOR gain, leading to a sensory mismatch during head motion.
  • The vestibular system's function is reversibly impaired by remifentanil.
  • Avoiding vigorous head movements is recommended to prevent opioid-induced nausea.