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Related Experiment Videos

Experimental Brachiaria decumbens toxicity in cattle.

M M Noordin1, A Salam Abdullah, M A Rajion

  • 1Faculty of Veterinary Medicine and Animal Science, Universiti Pertanian Malaysia, Selangor.

Veterinary Research Communications
|January 1, 1989
PubMed
Summary

Rumen liquor from Brachiaria decumbens-intoxicated sheep caused liver and kidney dysfunction in cattle. Biochemical analysis revealed elevated liver enzymes, creatinine, and blood urea nitrogen, with reduced plasma bromosulphthalein clearance.

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Area of Science:

  • Veterinary Medicine
  • Animal Toxicology
  • Ruminant Physiology

Background:

  • Brachiaria decumbens is a common forage grass for cattle.
  • Previous studies indicated B. decumbens is not directly toxic to cattle when ingested.

Purpose of the Study:

  • To investigate the potential toxicity of rumen liquor from sheep intoxicated with B. decumbens when infused into cattle.
  • To identify biochemical markers indicative of hepatic and renal dysfunction.

Main Methods:

  • Infusion of rumen liquor from B. decumbens-intoxicated sheep into the rumen of cattle.
  • Monitoring of serum biochemical parameters including aspartate amino transferase, creatinine, and blood urea nitrogen.
  • Assessment of plasma bromosulphthalein clearance as a measure of liver function.

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Main Results:

  • Cattle receiving the infused rumen liquor showed evidence of hepatic and renal dysfunction.
  • Significant increases in serum aspartate amino transferase, serum creatinine, and blood urea nitrogen were observed.
  • A marked reduction in plasma bromosulphthalein clearance indicated impaired liver function.

Conclusions:

  • Rumen liquor from B. decumbens-intoxicated sheep can induce hepatic and renal dysfunction in cattle.
  • Biochemical changes suggest a toxic effect mediated through rumen microbial transfer.
  • Further research is needed to identify the specific toxic agents involved.