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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Updated: Apr 4, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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[Acute leukemia in adults].

E Eigendorff1, A Hochhaus

  • 1Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland, ekkehard.eigendorff@med.uni-jena.de.

Der Pathologe
|August 29, 2015
PubMed
Summary
This summary is machine-generated.

Advances in diagnostics and supportive care have improved outcomes for acute leukemia patients. Personalized treatment strategies, including stem cell transplants and targeted therapies, are becoming crucial for better patient prognosis.

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Area of Science:

  • Hematology
  • Oncology
  • Internal Medicine

Context:

  • Prognosis for adult acute leukemia has improved due to advancements in diagnostics, therapeutics, and supportive care.
  • Current treatment approaches involve sophisticated diagnostic and therapeutic procedures.

Purpose:

  • To provide an overview of current diagnostic and therapeutic options for acute leukemia.
  • To outline the clinical approach to diagnosing and treating acute leukemia in adults.

Summary:

  • Improved immunocytological and genetic procedures enable rapid and accurate diagnosis of acute leukemia.
  • Risk stratification using cytogenetic and molecular markers guides personalized treatment for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
  • Allogeneic stem cell transplantation and targeted therapies offer improved outcomes for specific patient subgroups, while supportive care advancements enhance overall prognosis.

Impact:

  • Enhanced diagnostic accuracy leads to more precise risk stratification and tailored therapeutic strategies.
  • Novel treatments like targeted therapies and improved supportive care significantly improve outcomes and quality of life for acute leukemia patients.
  • The increasing complexity necessitates specialized management in academic centers and clinical trials for optimal patient care.