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Update on the utility of corticosteroids in acute pediatric respiratory disorders

Avraham Beigelman1, Bradley E Chipps, Leonard B Bacharier

  • 1Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA.

Allergy and Asthma Proceedings
|August 29, 2015
PubMed

Insights

Corticosteroids effectively treat childhood asthma exacerbations and severe croup but offer no benefit for acute bronchiolitis or preschool wheezing. Further research is needed for specific treatment guidelines.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Corticosteroids are commonly used for pediatric acute respiratory illnesses.
  • Evidence supporting their efficacy varies significantly across conditions.

Purpose of the Study:

  • To review evidence on corticosteroid utility in common pediatric respiratory conditions.
  • To highlight controversies surrounding their use.

Main Methods:

  • Literature search of studies on systemic and inhaled corticosteroids.
  • Focused on acute asthma, preschool wheeze, croup, and bronchiolitis.

Main Results:

  • Systemic corticosteroids benefit school-age asthma exacerbations and severe croup.
  • Inhaled corticosteroids show promise for asthma in emergency settings.
  • No proven benefit for preschool wheeze; use discouraged in bronchiolitis.

Conclusions:

  • Corticosteroid response differs among pediatric respiratory conditions.
  • Research needed to identify phenotypes benefiting from corticosteroids, especially in preschool wheeze.
Abstract

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