Related Experiment Video
Updated: Apr 4, 2026
08:32
Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
Published on: March 27, 2019
6.5K
NKX6.3 controls gastric differentiation and tumorigenesis
Jung Hwan Yoon1, Won Suk Choi1, Olga Kim1
1Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Korea.
Oncotarget
|August 29, 2015
Summary
NKX6.3 acts as a gastric tumor suppressor by inhibiting cancer cell growth and promoting differentiation. Its reduced expression in gastric cancers suggests a critical role in preventing stomach cancer development.
Area of Science:
- Molecular Biology
- Oncology
- Gastroenterology
Background:
- NKX6.3 is a transcription factor crucial for gastric mucosal epithelial differentiation.
- Its role in gastric carcinogenesis remains to be fully elucidated.
Purpose of the Study:
- To investigate the tumor suppressive function of NKX6.3 in gastric cancer.
- To explore the molecular mechanisms underlying NKX6.3's action.
Main Methods:
- Analysis of NKX6.3 expression in gastric cancer tissues.
- Overexpression studies in gastric cancer cell lines (AGSNKX6.3, MKN1NKX6.3).
- Cell cycle, apoptosis, differentiation marker analysis, and ChIP-cloning/sequencing.
Main Results:
- NKX6.3 expression is reduced in gastric cancers.
- NKX6.3 overexpression inhibits proliferation, induces apoptosis, and promotes gastric differentiation.
- NKX6.3 directly upregulates GKN1, a gastric tumor suppressor.
Conclusions:
- NKX6.3 functions as a tumor suppressor in gastric carcinogenesis.
- NKX6.3 regulates gastric cell fate through modulation of cell cycle, differentiation, and apoptosis.
- NKX6.3 and GKN1 cooperate in gastric tumor suppression.
Related Concept Videos
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
01:56Gastrulation
69.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
69.2K
03:14Notch Signaling Pathway
6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
01:19Cadherins in Tissue Organization
4.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
4.5K
02:38The Ras Gene
7.5K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
7.5K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.8K