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Neural reward processing in individuals remitted from major depression.

B Ubl1, C Kuehner2, P Kirsch3

  • 1Department of Cognitive and Clinical Neuroscience,Central Institute of Mental Health,Medical Faculty Mannheim,Heidelberg University,Mannheim,Germany.

Psychological Medicine
|August 29, 2015
PubMed
Summary

Individuals in remission from major depressive disorder (rMDD) show heightened neural responses to reward cues in fronto-limbic regions. This suggests increased effort in executive and evaluative processes during reward anticipation.

Keywords:
Functional magnetic resonance imagingremitted depressionrewardtemperament

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Dysfunctional reward processing is observed in active depression.
  • Limited understanding exists regarding reward processing in individuals with remitted major depressive disorder (rMDD).

Purpose of the Study:

  • To investigate neural alterations in reward processing among individuals with remitted major depressive disorder (rMDD).
  • To explore the association between personality traits (reward dependence, novelty seeking, harm avoidance) and neural responses to reward in rMDD.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess brain activity during a reward task.
  • 23 individuals with rMDD and 23 healthy controls (HCs) participated.
  • The Tridimensional Personality Questionnaire (TPQ) assessed personality traits.

Main Results:

  • Individuals with rMDD exhibited heightened neural responses to reward-predicting cues in the hippocampus, amygdala, and superior frontal gyrus compared to HCs.
  • No significant differences in neural responses were observed when rewards were delivered.
  • Neural activity during reward anticipation negatively correlated with harm avoidance in both groups.

Conclusions:

  • Remitted major depressive disorder (rMDD) is associated with hyperactivation in fronto-limbic regions during reward anticipation.
  • These neural alterations may indicate increased effort in executive and evaluative functions related to reward anticipation in rMDD.
  • Understanding these neural patterns is crucial for potential therapeutic interventions.