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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Dipolar motions and ionic conduction in an ibuprofen derived ionic liquid.
M T Viciosa1, G Santos, A Costa
1CQFM - Centro de Química-Física Molecular and IN - Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001 Lisboa, Portugal. teresaviciosa@ist.utl.pt.
Physical Chemistry Chemical Physics : PCCP
|August 29, 2015
Summary
Researchers enhanced ibuprofen solubility by combining it with an ionic liquid, creating a water-miscible compound. This novel ibuprofen-ionic liquid material exhibits unique phase transitions and dynamic behaviors sensitive to water content.
Area of Science:
- Materials Science
- Physical Chemistry
- Pharmaceutical Science
Background:
- Poor water solubility of active pharmaceutical ingredients (APIs) like ibuprofen limits their bioavailability and formulation options.
- Ionic liquids (ILs) offer tunable properties for drug delivery and material design.
- Understanding the physical behavior of IL-API systems is crucial for developing advanced pharmaceutical formulations.
Purpose of the Study:
- To investigate the formation and properties of an ionic liquid-ibuprofen (IL-API) conjugate.
- To characterize the phase behavior and dynamics of the IL-API system with varying water content.
- To explore the potential of IL-API systems as novel drug delivery platforms.
Main Methods:
- Synthesis of an ionic liquid-ibuprofen conjugate using 1-ethanol-3-methylimidazolium ([C2OHMIM]) cation and ibuprofen.
- Dielectric relaxation spectroscopy (DRS) to probe dynamical behavior across a range of temperatures and water concentrations.
- Conductivity, electrical modulus, and complex permittivity analyses.
- Temperature-modulated differential scanning calorimetry (TMDSC) to confirm structural relaxation times.
Main Results:
- The IL-API conjugate exhibited a remarkable increase in ibuprofen solubility (approx. 5 orders of magnitude) and high water miscibility.
- Phase transformations (crystallization, glass transition) were highly sensitive to water content, with dehydration shifting glass transition to higher temperatures.
- DRS revealed multiple reorientational dipolar processes, with a dominant coupled charge transport and dipolar mechanism (σ-process) near the glass transition.
- Secondary relaxation (β-relaxation) was identified as a Johari-Goldstein (βJG) process, typical of molecular glass formers.
Conclusions:
- The combination of ibuprofen with the [C2OHMIM] ionic liquid creates a highly soluble and water-miscible IL-API system.
- The IL-API system displays complex dynamics, behaving as a hybrid of a molecular glass former and an ionic conductor.
- Water content significantly influences the phase behavior and dynamics, offering a route for tuning material properties.
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