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[Tissue concentrations of beta-methyl-digoxin in children]
J Ardura1, M P Aragón, A Khatib
1Departamento de Pediatría, Facultad de Medicina, Valladolid.
Anales Espanoles De Pediatria
|September 1, 1989
Summary
Beta-methyl-digoxin tissue concentrations, similar to digoxin, were analyzed in heart surgery patients. Myocardial tissue showed higher concentrations post-circulation, unlike adipose and skeletal muscle.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Biochemistry
Context:
- Investigating drug distribution in human tissues is crucial for understanding therapeutic efficacy and potential toxicity.
- Congenital heart disease necessitates complex surgical interventions, often involving extracorporeal circulation.
- Cardiac glycosides, like digoxin, are vital in managing heart failure and arrhythmias.
Purpose:
- To quantify beta-methyl-digoxin concentrations in adipose, skeletal muscle, and myocardial tissues.
- To analyze the correlation between dosage, plasma levels, and tissue distribution of beta-methyl-digoxin.
- To compare the tissue distribution of beta-methyl-digoxin with that of digoxin.
Summary:
- Beta-methyl-digoxin exhibited statistically significant correlations between dosage, plasma concentrations, and skeletal muscle concentrations.
- Myocardial tissue demonstrated significantly higher beta-methyl-digoxin concentrations compared to adipose tissue before extracorporeal circulation.
- Extracorporeal circulation led to decreased concentrations in adipose and skeletal muscle but increased myocardial concentrations.
Impact:
- Findings suggest beta-methyl-digoxin behaves similarly to digoxin regarding tissue distribution.
- This study provides insights into the pharmacokinetics of beta-methyl-digoxin in cardiac patients.
- Understanding tissue-specific drug accumulation is essential for optimizing dosing and minimizing adverse effects in cardiovascular pharmacotherapy.