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Related Experiment Videos

[Disaccharidases: 25 years later].

I Polanco Allúe, R Codoceo Alquinta, P Fernández Calle

    Anales Espanoles De Pediatria
    |September 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Oligosaccharidase activity is significantly reduced in various gastrointestinal conditions, influenced by mucosal damage and underlying causes. Other factors exacerbate these alterations compared to healthy individuals.

    Area of Science:

    • Gastroenterology and Digestive Physiology
    • Biochemistry of Enzymes
    • Clinical Diagnostics

    Context:

    • Investigating alterations in oligosaccharidase activity in patients with gastrointestinal disorders.
    • Understanding the impact of mucosal damage and etiological factors on enzyme function.
    • Comparing enzyme activity in patient groups to healthy subjects.

    Purpose:

    • To identify key factors contributing to oligosaccharidase alteration.
    • To quantify the decrease in oligosaccharidase activity in specific patient cohorts.
    • To highlight the variability in analytical methodologies and the importance of reference values.

    Summary:

    • Major factors influencing oligosaccharidase alteration include histological mucosal damage and etiological diagnosis.

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  • Additional factors like bacterial overgrowth and malnutrition further increase enzyme alteration.
  • Significantly decreased oligosaccharidase activity was observed in conditions such as DGR, IPLV, celiac disease with mucosal alterations, and SPG with APM, even in cases without histological damage.
  • Impact:

    • Provides insights into the biochemical basis of digestive disorders.
    • Highlights the diagnostic relevance of measuring oligosaccharidase activity.
    • Emphasizes the need for standardized analytical methods and laboratory-specific reference values for accurate clinical interpretation.