Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

5.1K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.1K
Oogenesis02:07

Oogenesis

71.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
71.4K
Oogenesis01:22

Oogenesis

5.0K
Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
5.0K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

2.3K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.3K
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

4.8K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.8K
Signs of Puberty01:27

Signs of Puberty

2.0K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Family Planning Decisions Among Women in the U.S. Military.

Military medicine·2026
Same author

Long-term amyloid PET and MRI outcomes in a menopausal hormone therapy trial.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

IGF-1R Antagonism in Thyroid Eye Disease and Female Reproductive Function.

Ophthalmic plastic and reconstructive surgery·2025
Same author

Association between central adiposity and cognitive domain function in recently postmenopausal women: an analysis from the KEEPS-Cog substudy of the Kronos Early Estrogen Preventive Study.

Menopause (New York, N.Y.)·2025
Same author

Diagnosis of Polycystic Ovary Syndrome and Non-Hispanic Black Race Are Predictive of Hypertension in Reproductive Age Women with Polycystic Ovary Syndrome.

Journal of women's health (2002)·2025
Same author

Novel Pharmacotherapies for Menopausal Symptoms.

Obstetrics and gynecology·2025
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.4K

Premature Menopause.

Saioa Torrealday1, Lubna Pal2

  • 1Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Womack Army Medical Center, 2817 Reilly Road, Fort Bragg, NC 28311, USA.

Endocrinology and Metabolism Clinics of North America
|August 29, 2015
PubMed
Summary
This summary is machine-generated.

Premature menopause affects 1% of women under 40, causing multisystem issues due to early ovarian steroid loss. An integrated approach is crucial for managing physical, psychological, and overall well-being in affected women.

Keywords:
Hypergonadotropic hypogonadismPremature menopausePremature ovarian failurePrimary ovarian insufficiencySurgical menopause

More Related Videos

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.7K
Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

1.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.4K
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.7K
Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

1.4K

Area of Science:

  • Reproductive Endocrinology
  • Women's Health
  • Menopause Studies

Background:

  • Premature menopause, affecting ~1% of women under 40, is a heterogeneous disorder.
  • Early ovarian steroid deprivation leads to multisystem implications.
  • This condition presents unique health challenges for a young population.

Purpose of the Study:

  • To highlight the multisystemic consequences of premature menopause.
  • To emphasize the need for comprehensive management strategies.
  • To address the physical and psychological health concerns of affected women.

Main Methods:

  • Review of existing literature on premature menopause.
  • Analysis of multisystemic sequelae.
  • Discussion of integrated management approaches.

Main Results:

  • Premature menopause results in significant health challenges due to early ovarian steroid deficiency.
  • The condition impacts multiple body systems.
  • A holistic management strategy is essential.

Conclusions:

  • Integrated management addressing physical, psychological, and overall well-being is paramount for women experiencing premature menopause.
  • Early diagnosis and intervention are crucial.
  • Further research into long-term management is warranted.