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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Anxious women do not show the expected decrease in cardiovascular stress responsiveness as pregnancy advances.

M A K A Braeken1, A Jones2, R A Otte3

  • 1Department of Psychology, Tilburg University, The Netherlands; REVAL Rehabilitation Research Center, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Belgium; Department of Psychology, KU Leuven, Belgium.

Biological Psychology
|August 29, 2015
PubMed
Summary
This summary is machine-generated.

Pregnancy alters stress responses, with anxious women showing less dampened reactivity over time. This may pose long-term risks for both mother and child, necessitating further research.

Keywords:
AnxietyAutonomic nervous systemHeart rate variabilityPregnancyStress responsiveness

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Area of Science:

  • Psychophysiology
  • Perinatal Mental Health
  • Stress Research

Background:

  • Altered stress responsiveness is a known risk factor for mental and physical illness.
  • Anxiety's impact on physiological stress regulation is established in non-pregnant individuals.
  • Understanding these effects during pregnancy is crucial for maternal and offspring well-being.

Purpose of the Study:

  • To investigate how pregnancy influences cardiovascular stress reactivity and recovery.
  • To examine the role of maternal anxiety in modulating stress responses during pregnancy.
  • To assess potential risks associated with altered stress reactivity in pregnant women.

Main Methods:

  • Longitudinal study design involving pregnant women.
  • Repeated exposure to mental arithmetic stress tasks in the first and third trimesters.
  • Measurement of cardiovascular stress reactivity (heart rate, heart rate variability) and trait anxiety (State-Trait Anxiety Inventory).

Main Results:

  • Cardiovascular stress reactivity was lower in the third trimester compared to the first trimester.
  • Anxious women exhibited less attenuation of stress reactivity as pregnancy progressed.
  • Heart rate and high-frequency heart rate variability changes indicated these differences.

Conclusions:

  • Pregnancy significantly influences stress reactivity, with a dampening effect observed over time.
  • Higher maternal anxiety is associated with diminished stress response habituation during pregnancy.
  • These findings suggest potential long-term risks for anxious pregnant women and their offspring, warranting further investigation.