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Allogeneic Precursor Cells for Systolic Heart Failure: A Need for Mechanisms in Humans

Stephen Farris1, April Stempien-Otero2

  • 1From the Department of Medicine, Division of Cardiology (S.F., A.S.-O.), and Institute for Stem Cell and Regenerative Medicine (A.S.-O.), University of Washington School of Medicine, Seattle. april@u.washington.edu.

Circulation Research
|August 29, 2015
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Editorialscardiacheart failureinflammationmesenchymal stromal cellsmyocytes

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Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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