Related Experiment Video
Updated: Apr 4, 2026
10:14
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
4.4K
Optical Coherence Tomography Monitoring Strategies for A-VEGF-Treated Age-Related Macular Degeneration: An
Ontario Health Technology Assessment Series
|August 29, 2015
Summary
Optical coherence tomography (OCT) and visual acuity (VA)-guided treat-as-needed (PRN) strategies reduce the burden of anti-vascular endothelial growth factor (A-VEGF) injections for neovascular age-related macular degeneration (n-AMD). Close monitoring and defined re-treatment criteria are crucial for success.
Area of Science:
- Ophthalmology
- Medical Retina
- Pharmacotherapy
Background:
- Anti-angiogenesis pharmacotherapies have transformed age-related macular degeneration (AMD) treatment.
- Monthly intraocular injections for AMD are burdensome and carry risks.
- Individual responses to anti-vascular endothelial growth factor (A-VEGF) therapy vary significantly.
Purpose of the Study:
- To review monitoring strategies for A-VEGF-treated neovascular AMD (n-AMD).
- To evaluate the role of optical coherence tomography (OCT) in guiding n-AMD management.
- To assess strategies for reducing treatment burden while maintaining efficacy.
Main Methods:
- Systematic review of studies from 2008-2013 on A-VEGF-treated n-AMD patients.
- Analysis of randomized controlled trials (RCTs) and observational studies.
- Comparison of various monitoring schedules and re-treatment protocols.
Main Results:
- Several maintenance strategies were less effective than monthly injections.
- Treat-as-needed (PRN) strategies with monthly monitoring and OCT/VA assessment decreased injection frequency.
- PRN strategies maintained visual gains but were slightly less effective than in clinical trials.
Conclusions:
- OCT/VA-guided PRN strategies are preferred for individualized n-AMD treatment.
- These strategies reduce treatment burden and improve patient management.
- Effective implementation requires close monitoring and strict re-treatment criteria.
More Related Videos
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K