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Published on: September 15, 2017
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Preventing Heart Failure in Inflammatory and Immune Disorders
Maya Serhal1, Chris T Longenecker2
1University Hospitals Case Medical Center, Cleveland, OH, USA.
Current Cardiovascular Risk Reports
|August 29, 2015
Summary
Patients with chronic inflammatory diseases face higher heart failure risks. This review explores anti-inflammatory therapies and lifestyle changes to prevent heart failure in these populations.
Area of Science:
- Cardiology
- Rheumatology
- Infectious Diseases
Background:
- Chronic inflammatory diseases, such as rheumatoid arthritis and treated HIV infection, elevate heart failure risk.
- This risk stems from ischemic heart disease and heart failure with preserved ejection fraction.
- Understanding these risks is crucial for targeted prevention strategies.
Purpose of the Study:
- To review the epidemiology of heart failure in patients with chronic inflammatory diseases.
- To explore potential therapeutic strategies for preventing heart failure in these at-risk populations.
- To adapt existing heart failure prevention models for chronic inflammatory disease contexts.
Main Methods:
- Literature review focusing on epidemiology and therapies for heart failure in rheumatoid arthritis and treated HIV.
- Analysis of anti-inflammatory treatments, including statins and biologic disease-modifying drugs.
- Evaluation of evidence for lifestyle modifications and renin-angiotensin-aldosterone system blockade.
Main Results:
- Patients with chronic inflammatory diseases exhibit increased susceptibility to heart failure.
- Anti-inflammatory therapies, statins, and biologic drugs show promise in prevention.
- Limited evidence supports lifestyle changes and RAAS blockade for heart failure prevention in this cohort.
Conclusions:
- Heart failure prevention in chronic inflammatory diseases requires a multi-faceted approach.
- Adapting models like the Screening To Prevent Heart Failure (STOP-HF) trial is a viable strategy.
- Targeted interventions focusing on inflammation reduction are key to mitigating heart failure risk.
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