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Extraintestinal Involvement of Rotavirus Infection in Children

Somayeh Jalilvand1, Sayed Mahdi Marashi1, Abbas Tafakhori2

  • 1Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Archives of Iranian Medicine
|August 29, 2015
PubMed

Insights

Rotaviruses (RVs) can spread beyond the gut in children with acute gastroenteritis (AGE), reaching organs like the brain. RV RNA and antigen are detectable in blood and cerebrospinal fluid (CSF) during systemic infections.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Rotaviruses (RVs) are a leading cause of severe diarrhea in young children globally.
  • While primarily infecting the gastrointestinal tract, RVs can cause systemic infections.

Purpose of the Study:

  • To investigate the extraintestinal spread of Rotaviruses (RVs) in children with acute gastroenteritis (AGE).
  • To determine the presence of RV components in systemic sites during infection.

Main Methods:

  • Detection of RV RNA, antigen, and infectious particles in serum, cerebrospinal fluid (CSF), and extraintestinal tissues.
  • Molecular genotyping of paired stool and serum samples.

Main Results:

  • RV RNA, antigen, and infectious particles were found in serum, CSF, and extraintestinal tissues of children with AGE.
  • Nucleotide changes and genotype discordance were observed between stool and serum samples.
  • RV genome was detectable in extraintestinal organs in children with evidence of antigenemia.

Conclusions:

  • Rotavirus (RV) infections can extend beyond the gastrointestinal tract, leading to systemic spread.
  • The presence of RV in systemic sites like CSF suggests potential for broader clinical manifestations.
  • Further research is needed to clarify the clinical significance of these extraintestinal findings.

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