Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
6.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

14.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
14.0K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

11.0K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.

RMD open·2026
Same author

Tumor-preserving Deformable Registration of Longitudinal DCE Breast MRI during Neoadjuvant Chemotherapy.

Radiology. Artificial intelligence·2026
Same author

Generating synthetic CEM from low-energy images using deep learning: A future without contrast media? A proof-of-concept study.

European radiology experimental·2026
Same author

The association between loneliness and suicide ideation: A cross-sectional comparison of Latin American immigrants and Spanish natives in Spain.

Journal of affective disorders·2026
Same author

Vaccination coverage among adolescent athletes: Patterns, gaps, and implications for sports medicine.

Human vaccines & immunotherapeutics·2025
Same author

Deep Learning-Driven Computational Approaches for Studying Intrinsically Disordered Regions in S100-A9.

Methods in molecular biology (Clifton, N.J.)·2025

Related Experiment Video

Updated: Apr 4, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Biological therapy induces expression changes in Notch pathway in psoriasis.

Evangelia Skarmoutsou1, Chiara Trovato1, Mariagrazia Granata1

  • 1Department of Biomedical and Biotechnological Sciences, University of Catania, via Androne 83, 95124, Catania, Italy.

Archives of Dermatological Research
|August 31, 2015
PubMed
Summary

This study investigated the Notch pathway in psoriasis, finding its components upregulated in patients. Biological treatments for psoriasis downregulated these Notch pathway molecules, suggesting they are potential therapeutic targets.

Keywords:
Biological therapyIL-12/IL-23p40Notch pathwayPsoriasisTNF-α

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K

Related Experiment Videos

Last Updated: Apr 4, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin disease driven by keratinocyte hyperproliferation and T-cell infiltration.
  • The precise pathophysiology of psoriasis remains incompletely understood.
  • The Notch pathway is crucial for cell fate, proliferation, differentiation, and immune function.

Purpose of the Study:

  • To investigate the expression of Notch pathway components (NOTCH1, NOTCH2, JAGGED1, HES1) in psoriatic skin.
  • To analyze the impact of biological therapies on Notch pathway component expression in psoriasis patients.

Main Methods:

  • Real-time RT-PCR was used to quantify mRNA expression levels.
  • Western blot and immunohistochemistry were employed to assess protein expression levels.
  • Skin samples from untreated psoriatic patients and normal controls were analyzed, along with samples post-biological treatment.

Main Results:

  • mRNA and protein levels of NOTCH1, NOTCH2, JAGGED1, and HES1 were significantly upregulated in untreated psoriatic skin compared to normal controls.
  • Biological therapies demonstrated varied downregulation effects on the protein expression of these Notch pathway molecules.
  • Specific biological agents evaluated included TNF-α inhibitors and anti-IL-12/IL-23 p40 antibodies.

Conclusions:

  • Components of the Notch pathway are upregulated in psoriatic skin.
  • Biological treatments modulate the expression of Notch pathway molecules in psoriasis.
  • The Notch pathway represents a potential therapeutic target for managing psoriasis.