Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Commentary on: A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8658 Cycles in 2114 Patients.

Aesthetic surgery journal·2021

Same author

Radiation and depression associated with complications of tissue expander reconstruction.

Breast cancer research and treatment·2017

Same author

Reducing the incidence of hematoma requiring surgical evacuation following male rhytidectomy: a 30-year review of 985 cases.

Plastic and reconstructive surgery·2005

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 4, 2026

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Published on: July 28, 2018

Adipose Hypertrophy Following Cryolipolysis.

William A Stefani¹

¹Dr Stefani is an Associate Professor, Oakland University School of Medicine, Rochester, MI.

Aesthetic Surgery Journal

|August 31, 2015

Summary

Cryolipolysis effectively reduces fat but can cause pain. A rare complication is an enlarging adipose collection after treatment, as seen in one patient.

Area of Science:

Plastic Surgery
Dermatology
Cosmetic Procedures

Background:

Cryolipolysis is a popular non-invasive method for reducing localized fat deposits.
Commonly reported side effects include pain, though typically mild with minimal downtime.
The procedure utilizes controlled cooling to induce adipocyte apoptosis.

Observation:

A patient developed an enlarging adipose collection in the lower abdomen post-cryolipolysis.
This occurred after undergoing the CoolSculpting procedure.
The collection appeared to be a paradoxical adipose hyperplasia.

Findings:

Paradoxical adipose hyperplasia is a rare but documented adverse effect of cryolipolysis.
This condition involves an increase in fat volume instead of reduction.

More Related Videos

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Published on: September 27, 2021

Related Experiment Videos

Last Updated: Apr 4, 2026

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Published on: July 28, 2018

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Published on: September 27, 2021

The exact mechanism causing this reaction remains under investigation.

Implications:

Clinicians should be aware of paradoxical adipose hyperplasia as a potential complication of cryolipolysis.
Further research is needed to understand the risk factors and underlying mechanisms.
This highlights the importance of patient selection and monitoring for adverse events in non-invasive body contouring.