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Left ventricular structural and functional abnormalities in dogs with hyperadrenocorticism.

Hiroshi Takano1, Akira Kokubu1, Keisuke Sugimoto1

  • 1Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
|August 31, 2015
PubMed
Summary
This summary is machine-generated.

Hyperadrenocorticism commonly causes left ventricular (LV) hypertrophy in dogs, irrespective of systemic hypertension. This condition should be considered in canine patients presenting with LV structural changes.

Keywords:
CanineConcentricCushing'sHypertrophy

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Area of Science:

  • Cardiology
  • Veterinary Medicine
  • Endocrinology

Background:

  • Hyperadrenocorticism is known to induce left ventricular (LV) abnormalities in humans.
  • Canine hyperadrenocorticism involves excessive cortisol production, potentially impacting cardiovascular health.

Purpose of the Study:

  • To determine the prevalence and characteristics of LV structural and functional changes in dogs with hyperadrenocorticism.
  • To investigate the relationship between hyperadrenocorticism and cardiac remodeling in dogs.

Main Methods:

  • Echocardiographic assessments were conducted on 22 dogs diagnosed with hyperadrenocorticism (pituitary-dependent or adrenocortical tumors) and 6 healthy controls.
  • Non-invasive systolic blood pressure (SBP) measurements were obtained for all dogs.

Main Results:

  • Dogs with hyperadrenocorticism exhibited significantly different normalized LV wall thickness and LV mass index compared to controls.
  • 68% of affected dogs (15/22) showed increased LV wall thickness, with 73% of these being normotensive.
  • No significant correlation was found between increased LV wall thickness and SBP in affected dogs.

Conclusions:

  • Left ventricular hypertrophy is a common finding in dogs with hyperadrenocorticism.
  • Hyperadrenocorticism should be considered in the differential diagnosis for dogs presenting with LV hypertrophy, even in the absence of hypertension.
  • These findings highlight the cardiovascular impact of hyperadrenocorticism in canine patients.