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Related Experiment Video

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Systemic lupus erythematosus and malignancies risk.

Song Mao1, Hua Shen2, Jianhua Zhang3

  • 1Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. edjh123456@sina.com.

Journal of Cancer Research and Clinical Oncology
|August 31, 2015
PubMed
Summary

Systemic lupus erythematosus (SLE) patients face a higher risk of overall malignancies, especially Asians and females. Increased age and SLE duration are linked to a reduced malignancy risk in these patients.

Keywords:
MalignancyMeta-analysisSystemic lupus erythematosus

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Area of Science:

  • Rheumatology
  • Oncology
  • Epidemiology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with complex health implications.
  • Understanding the associated risks of malignancy in SLE patients is crucial for comprehensive patient care.

Purpose of the Study:

  • To evaluate the risk of developing site-specific and overall malignancies in patients with SLE.
  • To identify potential factors influencing malignancy risk in SLE patients.

Main Methods:

  • A systematic literature search was conducted on electronic databases up to February 2015.
  • Pooled incidence rates (IRs) and 95% confidence intervals (CIs) were calculated using random effects models.
  • Impact of study design, region, gender, age, and SLE duration on malignancy risk was assessed.

Main Results:

  • Eighteen studies revealed a pooled IR of 1.44 for overall malignancies in SLE patients.
  • Higher IRs were observed in Asians (1.62) and females (1.51).
  • Increased risks were noted for non-Hodgkin lymphoma, hematologic, head/neck, lung, and other specific cancers, while ovary and colon/rectum cancers showed decreased risks.

Conclusions:

  • SLE patients exhibit an elevated risk of overall malignancies, notably in Asian and female populations.
  • Risk of malignancy decreases with increasing age and duration of SLE.
  • SLE influences the incidence of various site-specific malignancies differently.