Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

854
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
854
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

762
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
762
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

2.1K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
2.1K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

583
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
583
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

651
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
651
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

921
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
921

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA.

Molecular biology of the cell·2015
Same author

Overcoming difficulty in diagnosis and differential diagnosis of Crohn's disease: the potential role of serological and genetic tests.

Expert review of molecular diagnostics·2015
Same author

The presence of primary sclerosing cholangitis in patients with ileal pouch anal- anastomosis is associated with an additional risk for vitamin D deficiency.

Gastroenterology report·2015
Same author

Perioperative Blood Transfusion and Postoperative Outcome in Patients with Crohn's Disease Undergoing Primary Ileocolonic Resection in the "Biological Era".

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2015
Same author

Postoperative Fluid Overload is a Useful Predictor of the Short-Term Outcome of Renal Replacement Therapy for Acute Kidney Injury After Cardiac Surgery.

Medicine·2015
Same author

Intranuclear biophotonics by smart design of nuclear-targeting photo-/radio-sensitizers co-loaded upconversion nanoparticles.

Biomaterials·2015

Related Experiment Video

Updated: Apr 4, 2026

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

1.0K

Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis.

Custon T Nyabanga1, Geeta Kulkarni2, Bo Shen3

  • 1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Gastroenterology Report
|August 31, 2015
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) effectively treated chronic antibiotic-refractory pouchitis in a patient with a history of ulcerative colitis. This approach improved endoscopic mucosal inflammation, suggesting HBOT’s therapeutic potential.

Keywords:
hyperbaric oxygen therapyischemic pouchitisrefractory pouchitis

More Related Videos

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.7K
Author Spotlight: Enhancing Coronary Artery Revascularization
05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

1.0K
Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.7K
Author Spotlight: Enhancing Coronary Artery Revascularization
05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.4K

Area of Science:

  • Gastroenterology
  • Surgical Innovation
  • Oxygen Therapy

Background:

  • Ulcerative colitis management can involve proctocolectomy and J-pouch construction.
  • Chronic antibiotic-refractory pouchitis is a challenging complication post-surgery.
  • Ischemic features can be present in refractory pouchitis.

Observation:

  • A 59-year-old male with ulcerative colitis developed chronic pouchitis post-J-pouch surgery.
  • The patient's condition was refractory to antibiotic treatment and showed ischemic signs.
  • Endoscopic evaluation revealed significant mucosal inflammation.

Findings:

  • Hyperbaric oxygen therapy (HBOT) involved 20 sessions of 100% oxygen at 2.5-3.0 ATA for 60-90 minutes.
  • Repeat pouchoscopy after HBOT demonstrated marked improvement in endoscopic mucosal inflammation.
  • HBOT increased tissue oxygenation, reduced hypoxia, modulated inflammation, and promoted healing.

Implications:

  • HBOT shows therapeutic promise for chronic antibiotic-refractory pouchitis.
  • This case highlights a potential treatment modality for complex pouchitis.
  • Understanding HBOT's mechanisms may elucidate pouchitis pathogenesis.