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Updated: Apr 4, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
[Lyme carditis]
Justyna Błaut-Jurkowska1, Maria Olszowska1, Magdalena Kaźnica-Wiatr1
1Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Cracow, Poland.
Insights
Lyme carditis, a rare complication of Lyme disease, typically presents with conduction abnormalities and is treated with antibiotics. While usually benign, it can lead to serious heart issues and poses diagnostic challenges.
Area of Science:
- Infectious Diseases
- Cardiology
- Epidemiology
Background:
- Lyme disease, caused by Borrelia burgdorferi, is increasing in Poland and Europe.
- Cardiac involvement (Lyme carditis) affects 0.5-10% of Lyme disease patients, usually early in the illness.
- Manifestations include conduction abnormalities, arrhythmias, myocarditis, and pericarditis.
Purpose of the Study:
- To summarize the current understanding of Lyme carditis.
- To highlight diagnostic and therapeutic challenges associated with Lyme carditis.
Main Methods:
- Literature review of Lyme carditis cases and clinical presentations.
- Analysis of diagnostic difficulties and treatment outcomes.
Main Results:
- Lyme carditis commonly presents as transient conduction abnormalities or arrhythmias.
- Antibiotic therapy is the primary treatment, with most patients experiencing full recovery.
- Rarely, dilated cardiomyopathy or fatal outcomes can occur.
Conclusions:
- Lyme carditis is a significant, though uncommon, complication of Lyme disease.
- Diagnosis can be challenging due to atypical symptoms and variable serological results.
- Prompt diagnosis and treatment are crucial for favorable outcomes, despite potential for severe complications.
Abstract:
Lyme disease is a multisystem infectious disease caused by the spirochete Borrelia burgdorferi. A steady increase in the number of cases is noticed both in Poland and Europe. Cardiac involvement in the course of borreliosis is relatively rare. It is estimated that it concerns about 0.5-10% of patients with Lyme disease. Cardiac involvement generally occurs in the early phase of illness. The most common manifestation of Lyme carditis are transient conduction abnormality, arrhythmias, myocarditis and pericarditis. The basic method of treatment Lyme carditis are antibiotics. The clinical course is usually benign. In most cases a complete recovery is observed. However, in a small proportion of patients dilated cardiomyopathy may occur. Furthermore, death from Lyme carditis has been reported. Lyme carditis remains a real diagnostic and therapeutic challenge for clinicians. Factors that can make the diagnosis difficult are: atypical clinical picture, negation of tick bite, the absence of erythema migrans, onset of symptoms outside the period of tick activity and negative serological results in the initial stage of the disease.
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