Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.8K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
Bone Remodeling01:40

Bone Remodeling

41.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.1K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

3.3K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
3.3K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

8.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.5K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

6.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European society of gynecology (ESG) position paper on the proposed terminology change from PCOS to PMOS.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same author

Contemporary Approaches Towards the Optimization of Embryo Implantation.

Journal of clinical medicine·2026
Same author

Higher BMI is associated with vaginal microbiome alterations in women with PCOS.

Reproduction & fertility·2026
Same author

The Impact of the Menopausal Transition on Body Composition and Abdominal Fat Redistribution.

Journal of clinical medicine·2026
Same author

The Use of Stem Cells in Assisted Reproduction.

Journal of clinical medicine·2025
Same author

The Final Phases of Ovarian Aging: A Tale of Diverging Functional Trajectories.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Apr 4, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.5K

[Hyperprolactinaemia and bone mineral density].

Anna Kostrzak1, Błażej Męczekalski1

  • 1Department of Gynecological Endocrinology, Medical University of Poznań, Poland.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|August 31, 2015
PubMed
Summary
This summary is machine-generated.

High prolactin levels (hyperprolactinaemia) are common and can lead to infertility and metabolic issues. This condition also significantly increases the risk of osteoporosis and bone fractures.

Keywords:
bone fracturesbone mineral densityhyperprolactinaemiaosteoporosisprolactin

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

89.5K
Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.5K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

89.5K
Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.4K

Area of Science:

  • Endocrinology
  • Bone Metabolism

Context:

  • Hyperprolactinaemia, a common endocrine disorder in reproductive-aged women, stems from elevated prolactin levels.
  • Prolactin, primarily involved in lactation, also influences metabolic processes and bone health.
  • Symptoms range from reproductive dysfunction to increased cardiovascular and immunological risks.

Purpose:

  • To summarize the multifaceted effects of hyperprolactinaemia.
  • To highlight the association between elevated prolactin and decreased bone mineral density.
  • To emphasize the increased risk of osteopenia, osteoporosis, and fractures.

Summary:

  • Hyperprolactinaemia is linked to reproductive issues, metabolic disturbances, and cardiovascular risks.
  • Elevated prolactin levels directly impair bone health and contribute to hypoestrogenism, reducing bone mineral density (BMD).
  • This significantly elevates the risk of osteopenia, osteoporosis, and fractures, particularly in cases of prolactinoma or antipsychotic drug use.

Impact:

  • Underscores the importance of early diagnosis and treatment of hyperprolactinaemia.
  • Recommends screening for osteopenia and osteoporosis in affected patients.
  • Highlights the need for prompt management to mitigate long-term skeletal and systemic health consequences.