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Histological Structure and Vascularity of Hysteroscopically Removed Uterine Septa in Patients With Primary
Ghada Abdel Fattah Abdel Moety1, Hassan Mostafa Gaafar1, Osama Shawki1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Objective:
To examine the histological structure and vascularity of uterine septa in patients with unexplained primary infertility and patients with recurrent pregnancy loss (RPL).
Design:
Case-control study (Canadian Task Force classification II-2).
Setting:
Kasr Al Aini Hospital, Cairo University, Egypt.
Patients And Interventions:
A total of 41 patients with uterine septa presenting with either unexplained primary infertility or RPL underwent 3-dimensional (3D) and power Doppler (PD) ultrasound to calculate the septum volume, septal vascularization index (VI), and myometrial VI. Hysteroscopically removed septa were examined histologically for myometrial and fibrous tissue content.
Measurements And Main Results:
Septal characteristics differed between the primary infertility group (24 patients) and the RPL group (17 patients). Mean septal VI was significantly higher in the RPL group compared with the infertility group (18.39% ± 7.57% vs 11.67% ± 4.56%; p = .003), as was septal myometrial area (20.74% ± 5.97% vs 13.57% ± 5.55%; p < .001). In both groups, septal VI was strongly correlated with myometrial VI and myometrial content, but not with fibrous tissue content.
Conclusion:
Uterine septa of patients with RPL are more vascularized and contain more muscular tissue compared with those of patients with primary unexplained infertility.
