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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Formation of Muscle Fibers from Myoblasts01:13

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Related Experiment Video

Updated: Apr 4, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Myositis Ossificans.

Brian E Walczak, Christopher N Johnson, B Matthew Howe

    The Journal of the American Academy of Orthopaedic Surgeons
    |August 31, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Myositis ossificans is a benign bone growth in soft tissue. Accurate diagnosis through imaging and biopsy is crucial for effective, multidisciplinary treatment of this ossifying lesion.

    Keywords:
    contusionheterotopic ossificationmyositis ossificans circumscriptapseudomalignant myositis ossificanssarcoma

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    Area of Science:

    • Orthopedics
    • Radiology
    • Pathology

    Background:

    • Myositis ossificans is a benign, self-limiting ossifying lesion affecting soft tissues.
    • Historically, ossifying soft-tissue lesions have faced inconsistent classification.
    • It can be categorized into nonhereditary and hereditary types, each with distinct pathophysiology and treatment.

    Purpose of the Study:

    • To review the classification, diagnosis, and treatment of myositis ossificans.
    • To highlight the importance of accurate diagnosis for successful patient outcomes.

    Main Methods:

    • Review of literature on myositis ossificans classification, etiology, and clinical presentation.
    • Discussion of diagnostic challenges, including advanced imaging and biopsy.
    • Emphasis on multidisciplinary approach for treatment planning.

    Main Results:

    • Myositis ossificans typically presents as a solitary ossifying soft-tissue mass.
    • Advanced imaging can be nonspecific, often requiring multiple modalities for diagnosis.
    • Histopathology findings vary depending on the lesion's stage of evolution.

    Conclusions:

    • Accurate diagnosis of myositis ossificans is fundamental for appropriate treatment.
    • A multidisciplinary approach is often necessary due to the complexity of diagnosis and treatment.
    • Distinguishing between hereditary and nonhereditary types is critical for management.