Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silk Ionomer-Based Modular Nanocoatings for Potential Immuno-Regenerative Cell Therapy in Osteoarthritis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Social and Demographic Health Disparities in Knee Osteoarthritis and Total Knee Arthroplasty.

Arthroplasty today·2026
Same author

Elucidating genes sufficient for viral entry into cells through sequential genome-wide CRISPR activation screens.

bioRxiv : the preprint server for biology·2026
Same author

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.

Science (New York, N.Y.)·2026
Same author

Intrinsic Viscoelasticity of Type II Collagen Contributes to the Viscoelastic Response of Immature Bovine Articular Cartilage Under Unconfined Compression Stress Relaxation.

Journal of biomechanical engineering·2026
Same author

Synovial fluid protects cartilage against fatigue failure in cyclical compression.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025

Related Experiment Video

Updated: Apr 4, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

11.3K

Porous titanium bases for osteochondral tissue engineering.

Adam B Nover1, Stephanie L Lee1, Maria S Georgescu1

  • 1Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA.

Acta Biomaterialia
|September 1, 2015
PubMed
Summary
This summary is machine-generated.

Tissue engineered osteochondral grafts using porous titanium and adult chondrocytes achieve native cartilage stiffness. This approach offers a promising cell-based alternative to allografts, with potential for structural optimization.

Keywords:
Articular cartilageOsteochondral graftsPorous titaniumTissue engineering

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.6K

Related Experiment Videos

Last Updated: Apr 4, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

11.3K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.6K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Surgery

Background:

  • Osteochondral grafts are essential for cartilage repair but face supply limitations.
  • Tissue engineering offers a cell-based alternative using hydrogels and porous metal scaffolds.
  • Porous titanium is a promising material for bone-like bases in osteochondral constructs.

Purpose of the Study:

  • To evaluate porous titanium as a base for tissue-engineered osteochondral grafts.
  • To assess the mechanical and biochemical properties of the engineered grafts.
  • To investigate the influence of the porous base on graft performance.

Main Methods:

  • Fabrication of osteochondral grafts with a chondrocyte-seeded hydrogel on a porous titanium base.
  • Culture of constructs using adult chondrocytes (a clinically relevant cell source).
  • Mechanical testing (Young's modulus) and biochemical analysis of the grafts.

Main Results:

  • Porous titanium supported cartilage growth to achieve native Young's modulus.
  • Engineered osteochondral constructs exhibited mechanical and biochemical properties comparable or superior to chondral-only controls.
  • Pore structure of the titanium base may influence fluid pressurization and strain, suggesting avenues for optimization.

Conclusions:

  • Tissue-engineered osteochondral grafts using porous titanium and adult chondrocytes can achieve native stiffness.
  • The selective laser melting manufacturing of porous titanium allows precise control over structural parameters.
  • Understanding the mechanical influence of the porous base is crucial for optimizing future graft designs.