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New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes
Ilirian Dhimitruka1, Timothy D Eubank2, Amy C Gross1
1Dorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.
Bioorganic & Medicinal Chemistry Letters
|September 1, 2015
Abstract:
A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.
Keywords:
2,4-Diamino-6-hydroxypyrimidine8-Aryl-7-deazaguanineCellular permeabilityFluorescent probesPhenacyl bromides
