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Novel splice variants of CXCR4 identified by transcriptome sequencing

L G L Sand1, A G Jochemsen2, E Beletkaia3

  • 1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Biochemical and Biophysical Research Communications
|September 1, 2015
PubMed
Summary

Researchers discovered two new CXCR4 splice variants in Ewing sarcoma cells. One variant showed functional cell membrane activity, while the other accumulated in the cytoplasm, highlighting the need for functional validation of novel isoforms.

Keywords:
Bone tumorsCXCR4Ewing sarcomaNext generation sequencingSoft tissue tumorSplicing

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