[Autoimmune hemolytic anemia: clinical analysis of 100 cases]

In 100 cases with autoimmune hemolytic anemia, Coombs test was directly positive in 77 cases (77%). 82 patients had warm autoantibodies. IgM was increased in 12 patients. 3 patients were diagnosed as lymphoma with titers more than 1:1024. One patient had paroxysmal cold hemoglobinuria. The dramatic clinical response to corticosteroid therapy was observed in patients with warm autoantibodies. However, immunosuppressor should be given to patients with cold autoantibodies. It was suggested that combined therapy with two drugs may be more effective than the use of corticosteroid alone. Of 6 patients in whom splenectomy was performed, 4 showed excellent results. Out of 100 cases, there were 23 with Evans syndrome.