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Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles
Timothy E Morey1, Manoj Varshney1, Jason A Flint1
1Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
Nano Letters
|September 1, 2015
Summary
Nanotechnology offers new ways to treat drug poisonings. Emulsion-based nanoparticles effectively removed bupivacaine from solutions and reduced its heart toxicity, showing promise for intoxication treatment.
Area of Science:
- Nanotechnology
- Materials Science
- Toxicology
Background:
- Nanotechnology enables the creation of nanoscale structures with high surface area-to-volume ratios.
- These properties present novel opportunities for treating drug poisonings.
Purpose of the Study:
- To investigate the potential of emulsion-based nanoparticles in treating bupivacaine intoxication.
- To compare the efficacy of nanoparticles versus macroemulsions in sequestering bupivacaine and mitigating cardiotoxicity.
Main Methods:
- Extraction of bupivacaine from aqueous solutions using emulsion-based nanoparticles (118.4 nm) and macroemulsions (432.0 nm).
- Assessment of bupivacaine sequestration from human blood.
- Evaluation of cardiotoxicity attenuation in guinea pig hearts.
Main Results:
- Nanoparticles demonstrated superior extraction of bupivacaine from physiological salt solutions compared to macroemulsions.
- Nanoparticles effectively sequestered bupivacaine from human blood.
- A greater attenuation of bupivacaine-induced cardiotoxicity was observed with nanoparticles in guinea pig hearts.
Conclusions:
- Emulsion-based nanoparticles show significant potential for treating bupivacaine intoxication.
- Nanoparticles are effective in sequestering the drug and reducing its toxic effects on the heart.
- Further investigation in animal models of intoxication is warranted.
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